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KMID : 0620920220540091379
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Experimental & Molecular Medicine
2022 Volume.54 No. 9 p.1379 ~ p.1389
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Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer
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Li Ye
Chen Zhuo-Kun
Duan Xu
Zhang He-Jing
Xiao Bo-Lin
Wang Kui-Ming
Chen Gang
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Abstract
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Mounting evidence indicates that tumor-derived exosomes (TDEs) play critical roles in tumor development and progression by regulating components in the tumor microenvironment (TME) in an autocrine or paracrine manner. Moreover, due to their delivery of critical molecules that react to chemotherapy and immunotherapy, TDEs also contribute to tumor drug resistance and impede the effective response of antitumor immunotherapy, thereby leading to poor clinical outcomes. There is a pressing need for the inhibition or removal of TDEs to facilitate the treatment and prognosis of cancer patients. Here, in the present review, we systematically overviewed the current strategies for TDE inhibition and clearance, providing novel insights for future tumor interventions in translational medicine. Moreover, existing challenges and potential prospects for TDE-targeted cancer therapy are also discussed to bridge the gaps between progress and promising applications.
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KEYWORD
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Cancer microenvironment, Targeted therapies
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